Euro News Source
No Result
View All Result
Monday, May 23, 2022
  • Login
  • Home
  • Latest News
    • All Europe
    • United Kingdom
      • England
      • Ireland
      • Scotland
      • Wales
    • France
    • Germany
    • Italy
    • Spain
    • Austria
    • Belgium
    • Netherlands
    • Switzerland
  • Economics
  • Politics
  • Health
  • Sports
  • Videosnew
Subscribe
Euro News Source
  • Home
  • Latest News
    • All Europe
    • United Kingdom
      • England
      • Ireland
      • Scotland
      • Wales
    • France
    • Germany
    • Italy
    • Spain
    • Austria
    • Belgium
    • Netherlands
    • Switzerland
  • Economics
  • Politics
  • Health
  • Sports
  • Videosnew
No Result
View All Result
Euro News Source
No Result
View All Result
Home Health

FOP: Origin of rare disease

by Francesco Mazzagatti
January 17, 2022
in Health
A A
0
152
SHARES
1.9k
VIEWS
FacebookTwitterLinkedin

The researchers studied muscle from mice with the same mutation in the ACVR1 gene that people with FOP have. They focused on two specific types of muscle tissue stem cells: fibro-adipogenetic progenitors (FAPs) and muscle stem cells (MuSCs). Typically, muscle injury repair requires a careful balance of these two cell types. Injured tissue responds by an expansion of FAP cells, which are assigned to recruit muscle stem cells that will regenerate the damaged muscle tissue. After about three days, FAPs die off, their job done. At the same time, MuSCs transition toward a more mature, differentiated state, called muscle fiber, essential to organized movement of our muscles.

In the mice with the ACVR1 mutation that Mourkioti, Shore, and their co-authors studied, apoptosis – the process through which FAP cells die as a part of proper muscle regeneration – had slowed significantly, leading to a high presence of FAPs past their usual lifespan. This altered their balance with the MuSCs. The injured tissue also showed a diminished capacity for muscle stem cell maturation and, as a result, muscle fibers were considerably smaller in mice carrying the ACVR1 mutation compared to muscle fibers in mice without the mutation.

“The prolonged persistence of diseased FAPs within the regenerating muscle contributes to the altered muscle environment in FOP, which reduces muscle regeneration and allows the over-abundant FAPs to contribute to the formation of extra-skeletal bone,” Mourkioti said. “This provides a completely new perspective on how excess extra-skeletal bone is formed – and how it could be prevented.”

The current targets for treating FOP focus on slowing extra-skeletal bone growth. This research may provide a pivotal new direction. “We propose that therapeutic interventions should consider promoting the regenerating potential of muscles together with the reduction of ectopic bone formation,” Shore and Mourkioti wrote. “By addressing both stem cell populations and their roles in the origin of FOP, there is the possibility of greatly enhanced therapies.”

The discovery was published in NPJ Regenerative Medicine.

Source: Perelman School of Medicine at the University of Pennsylvania

Source: Healthcare in Europe

Tags: Fibrodysplasia ossificans progressivarare disease

Related Posts

Health

Hyperpolarized nuclear MR: more precise diagnoses

May 23, 2022
Health

Smart pacifier monitors infant health

May 23, 2022
Health

Preventing deadly hospital infections without antibiotics

May 22, 2022
Health

Using the body’s own sugar to power implants and sensors

May 21, 2022
Health

Covid-19: immune reaction may cause amyloid generation

May 20, 2022
Health

Phage therapy: a viable alternative to antibiotics?

May 20, 2022
Please login to join discussion
  • Trending
  • Comments
  • Latest

Woman livestreams fatal stabbing of half-sister

October 25, 2021

Prison sentences for protestors who pray outside abortion clinics in Spain

February 4, 2022

Investigation opened into porn video recorded on altar of Flemish church

November 3, 2021

EU launches ‘Global Gateway’ to counter China’s Belt and Road

September 15, 2021
Freedom Day

Freedom Day

0
Fire Accident

Fire Accident In Iraq

0
Scotland

Advice from the Scotland Prime Minister

0
Brexiteers

Brexiteers Should Thank The EU

0

Adele Roberts seems on women’s magazine deal with with obvious stoma bag as she displays on most cancers prognosis

May 23, 2022

‘It was a mistake!’ – John McEnroe troubles Tim Henman around Wimbledon ban of Russian and Belarusian gamers

May 23, 2022

Charge of dwelling: Bank of England main hits back again at criticism it has ‘stoked inflation’

May 23, 2022

Tim Henman exceptional: Large names will not skip Wimbledon ATP, WTA ‘penalising’ players in position factors row

May 23, 2022

Recent Posts

Adele Roberts seems on women’s magazine deal with with obvious stoma bag as she displays on most cancers prognosis

May 23, 2022

‘It was a mistake!’ – John McEnroe troubles Tim Henman around Wimbledon ban of Russian and Belarusian gamers

May 23, 2022

Charge of dwelling: Bank of England main hits back again at criticism it has ‘stoked inflation’

May 23, 2022

Tim Henman exceptional: Large names will not skip Wimbledon ATP, WTA ‘penalising’ players in position factors row

May 23, 2022

Female tourist gang-raped by three men at a Spanish beach in Andalusia

May 23, 2022

Italy looking for two bids for airline ITA as deadline looms -sources

May 23, 2022

Recent Posts

  • Adele Roberts seems on women’s magazine deal with with obvious stoma bag as she displays on most cancers prognosis
  • ‘It was a mistake!’ – John McEnroe troubles Tim Henman around Wimbledon ban of Russian and Belarusian gamers
  • Charge of dwelling: Bank of England main hits back again at criticism it has ‘stoked inflation’
  • Tim Henman exceptional: Large names will not skip Wimbledon ATP, WTA ‘penalising’ players in position factors row
  • Female tourist gang-raped by three men at a Spanish beach in Andalusia

Categories

  • Austria
  • Bahamas
  • Belarus
  • Belgium
  • Breaking News
  • Brexiteers
  • Business
  • China
  • COVID Cases
  • Covid-19
  • Cyber security
  • Debt
  • Economics
  • Energy
  • England
  • Fashion
  • Fire Accident
  • France
  • Freedom Day
  • Germany
  • Health
  • Human Launch
  • Humanitarian
  • Ireland
  • Italy
  • Netherlands
  • News
  • Norway
  • Opinion
  • Politics
  • Refugees
  • Russia
  • Russia
  • Rwanda
  • Saudi Arabia
  • Scotland
  • Scotland
  • Spain
  • Spanish-Flu
  • Sports
  • Switzerland
  • Travel
  • Ukraine
  • United Kingdom
  • Videos
  • Wales
  • Zambia

Site Navigation

  • About
  • Advertise
  • Guest Post
  • Privacy Policy
  • Terms & Conditions
  • Contact Us
Euro News Source

Euro News Source is one of the best sources of European News. We provide the latest news from the European Union and its member states, local and international political, economic and sports news. Follow us to receive all news from around the European Union.

© 2021 Euro News Source.

No Result
View All Result
  • Home
  • Latest News
    • All Europe
    • United Kingdom
      • England
      • Ireland
      • Scotland
      • Wales
    • France
    • Germany
    • Italy
    • Spain
    • Austria
    • Belgium
    • Netherlands
    • Switzerland
  • Economics
  • Politics
  • Health
  • Sports
  • Videos

© 2021 Euro News Source.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Are you sure want to unlock this post?
Unlock left : 0
Are you sure want to cancel subscription?