The tests examined around 200 people with varying degrees of asthma, who were then followed up annually for five years. The group included smokers and non-smokers.The researchers found that people with asthma who experienced persistent airflow limitation, regardless of the severity of their asthma or their smoking status, exhibited constricted airways and also showed signs of lung tissue destruction.
The changes to lung tissue on CT scans in this subgroup of asthmatic patients were not associated with the typical inflammatory markers linked to bronchial asthma. This is important, because it could explain why conventional anti-inflammatory treatments are not as successful in this group. “Future studies should investigate the significance of lung destruction in the pathogenesis of asthma, which should enable us to achieve more personalized management of the disease in the future,” says Shimizu.
Source: Hokkaido University
Source: Healthcare in Europe