Portions of the left orbital-inferior frontal gyrus (a key region for language comprehension and production) and right orbital-inferior frontal gyrus (associated with various cognitive functions including attention, motor inhibition and imagery, as well as social cognitive processes) and the adjacent white matter areas made up the frontal lobe clusters.
The researchers also found a significant difference in the right ventral diencephalon region of the brain stem. This region is associated with many crucial bodily functions, including coordinating with the endocrine system to release hormones, relaying sensory and motor signals to the cerebral cortex and regulating circadian rhythms (the sleep-wake cycle). “This study points to serious long-term complications that may be caused by the coronavirus, even months after recovery from the infection,” Mishra said. “The present findings are from the small temporal window. However, the longitudinal time points across a couple of years will elucidate if there exists any permanent change.”
The researchers are conducting a longitudinal study on the same patient cohort to determine whether these brain abnormalities persist over a longer time frame.
Source: Radiological Society of North America
Source: Healthcare in Europe