Proposed model for the LCDR/hnRNP K/LAPTM5 axis promoting the pathogenesis of lung cancer
Source: GAO Shan
Led by Prof. GAO Shan from the Suzhou Institute of Biomedical Engineering and Technology of the Chinese Academy of Sciences (CAS), these scientists revealed that knockdown of the LCDR in lung cancer cells could promote apoptosis. Results were published in PNAS.
Lysosome is involved in cellular homeostasis and its dysregulation has been linked to various human diseases, including cancer. LncRNAs are noncoding RNAs with lengths longer than 200 nucleotides, whose dysregulation is associated with cancer hallmarks. They drive cancer growth and survival by interacting with DNA, RNA, and protein assemblies, including the heterogeneous ribonucleic acid protein (hnRNP) family, which functions as alternative splicing, RNA stability, and translation etc.
However, whether lncRNAs and/or hnRNPs are involved in lysosome-mediated cancer survival has not been elucidated.
In this study, LCDR binds to heterogeneous nuclear ribonucleoprotein K (hnRNP K) to regulate the stability of lysosomal-associated protein transmembrane 5 (LAPTM5) transcript that maintains the integrity of the lysosomal membrane.
Source: Healthcare in Europe
